Credit: UC San Diego Health Sciences
Brain organoids derived from a healthy person (left) compared to a person with focal cortical dysplasia (right).
Research Alert
Focal cortical dysplasia is a type of medication-resistant epilepsy. Since the cause is unknown, treatment options are limited to invasive brain surgery which may be ineffective. Now, UC San Diego School of Medicine researchers have developed a new human brain organoid model to study the mechanisms of this disease. The model helps the team uncover the involvement of RHOA — a gene that regulates cell-cell adhesion proteins — in neuronal proliferation.
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