Increasing numbers of individuals are developing chronic kidney disease (CKD), and many progress to end-stage renal disease (ESRD), which requires dialysis or a kidney transplant. Current guidelines recommend restricting dietary protein intake to help manage CKD and slow progression to ESRD; however, there is limited evidence that overall dietary protein restriction or limiting specific food sources of protein intake may slow kidney function decline in the general population.
To examine the relationship between dietary intake of major sources of protein and kidney function, a team led by Woon-Puay Koh, MBBS (Hons), PhD (Duke-NUS Medical School and Saw Swee Hock School of Public Health in National University of Singapore) analyzed data from the Singapore Chinese Health Study, a prospective study of 63,257 Chinese adults in Singapore. This is a population where 97% of red meat intake consisted of pork. Other food sources of protein included poultry, fish/shellfish, eggs, dairy products, soy, and legumes.
After an average follow-up of 15.5 years, the researchers found that red meat intake was strongly associated with an increased risk of ESRD in a dose-dependent manner. People consuming the highest amounts (top 25%) of red meat had a 40% increased risk of developing ESRD compared with people consuming the lowest amounts (lowest 25%) No association was found with intakes of poultry, fish, eggs, or dairy products, while soy and legumes appeared to be slightly protective. Substituting one serving of red meat with other sources of protein reduced the risk of ESRD by up to 62%.
“We embarked on our study to see what advice should be given to CKD patients or to the general population worried about their kidney health regarding types or sources of protein intake,” said Dr. Koh. “Our findings suggest that these individuals can still maintain protein intake but consider switching to plant-based sources; however, if they still choose to eat meat, fish/shellfish and poultry are better alternatives to red meat.”
Study co-authors include Jasmine Quan-Lan Lew, MD, Tazeen Hasan Jafar, MD, MPH, Hiromi Wai Ling Koh, MSc, Aizhen Jin, MD, Khuan Yew Chow, MD, and Jian-min Yuan, MD, PhD.
Disclosures: The authors reported no financial disclosures.
The article, entitled “Red Meat Intake and Risk of End-Stage Renal Disease,” will appear online at http://jasn.asnjournals.org/ on July 14, 2016, doi: 10.1681/ASN.2016030248.
The content of this article does not reflect the views or opinions of The American Society of Nephrology (ASN). Responsibility for the information and views expressed therein lies entirely with the author(s). ASN does not offer medical advice. All content in ASN publications is for informational purposes only, and is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This content should not be used during a medical emergency or for the diagnosis or treatment of any medical condition. Please consult your doctor or other qualified health care provider if you have any questions about a medical condition, or before taking any drug, changing your diet or commencing or discontinuing any course of treatment. Do not ignore or delay obtaining professional medical advice because of information accessed through ASN. Call 911 or your doctor for all medical emergencies.Since 1966, ASN has been leading the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients. ASN has nearly 16,000 members representing 112 countries. For more information, please visit www.asn-online.org or contact us at 202-640-4660.
RSS