Older adults with long-term alcohol dependence lose neurocognitive abilities

Researchers had 66 participants (35 women, 31 men), recruited from the Brown University Center for AIDS Research, undergo a comprehensive neurocognitive battery of testing. Current heavy drinkers (n=21) were classified using National Institute on Alcohol Abuse and Alcoholism criteria and structured clinical interviews and, further, were compared to non-drinkers and moderate drinkers (n=45). About 53 percent of the total population had a lifetime history of alcohol dependence (AD). Neurocognitive data were grouped according to global cognitive function, attention/executive function, learning, memory, motor function, verbal function, and speed of processing.

Results showed that current heavy drinking in older adults was associated with poorer global cognitive function, learning, memory, and motor function. Furthermore, a lifetime history of AD was associated with poorer function in the same neurocognitive domains, as well as the attention/executive domain, notwithstanding age. In summary, although current heavy drinking is associated with significant impairment in a number of neurocognitive domains, it appears that a history of AD is associated with lasting negative consequences for neurocognitive function.